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KMID : 0388120090180010015
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Journal of Korean Society for the Study of Obesity
2009 Volume.18 No. 1 p.15 ~ p.23
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The Relationship between Plasma Visfatin Level, Obesity and Metabolic Syndrome in Women Without Diabetes
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Kim Jung-Hwan
Cho Gum-Joo
Choi Kyung-Mook
Han Jee-Hye
Yoon Do-Kyung
Kim Sun-Mee
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Abstract
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Background: Visfatin is known to be secreted from visceral adipose tissue and have insulin-mimetic effect.
Therefore, visfatin is considered to be related to obesity, especially central obesity, insulin resistance and metabolic syndrome. However, results confirming these theories are not available. This study was conducted to investigate the
relationship between obesity, metabolic syndrome and serum visfatin concentration.
Methods: Total of 85 subjects were recruited. They were females of 30 to 60 years of aged who were not diagnosed as diabetics. The subjects were divided into normal weight group and obese group. They were further
divided into with or without metabolic syndrome groups. The serum visfatin levels of each group were compared. The correlation between serum visfatin concentration and biologic profiles were analyzed. Multiple linear regression analysis was done. All subjects were divided into 4 groups according to serum visfatin levels. Prevalence of metabolic syndrome and various variables related to metabolic syndrome of each group were compared.
Results: The serum visfatin in the obese group was significantly higher than that of the normal weight group
(P = 0.002). There was no significant difference in serum visfatin between with and without metabolic syndrome groups (P = 0.340). The serum visfatin had correlation with weight, body mass index, waist and hip circumference. There was no significant correlation between serum visfatin levels and prevalence of metabolic syndrome. Prevalence of high blood pressure, however, had a significant correlation with serum visfatin levels.
Conclusion: Obesity, especially central obesity, had a significant association with serum visfatin concentration
but failed to show any significant correlation with either metabolic syndrome or insulin resistance.
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KEYWORD
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Visfatin, Metabolic syndrome X, Insulin resistance
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